22 feb. VEGF AND CERVICAL INTRAEPITHELIAL NEOPLASIA: NEW INSIGHTS
Ioana Cristina Rotar*,**, D. Muresan *,**, Cristina Zlătescu**, F.Stamatian *,**
*- University of Medicine and Pharmacy „Iuliu Hatieganu”, Cluj Napoca, Romania
** – 1st Clinic of Obstetrics and Gynecology, Emergency County Hospital, Cluj Napoca, Romania
Rezumat: VEGF si neoplazia cervicală intraepitelială: noi perspective
Neoplazia cervicala intraepiteliala (CIN) reperezinta o leziune precursoare a cancerului de col uterin, aceasta fiind a patra cea mai frecventa in randul femeilor. Angiogeneza este pasul cheie in dezvoltarea tumorilor, proces in care VEGF joaca un rol esential. VEGF este secretat in cantitati mari de celulele neoplazice si de celulele din leziunile precursoare ale cancerului de col uterin. Aceste peptide stimuleaza cresterea si dezvoltarea celulelor endoteliale, proliferarea si diferentierea patului vascular, astfel cresterea tumorala. Multiple studii au demonstrat ca expresia VEGF in celulele cervicale se coreleaza seminifcativ cu severitatea leziunilor precursoare, a stadiului tumoral si cu prognosticul. Polimorfismele genetice contribuie la susceptibilitatea individului de a dezvolta cancer si cu severitatatea bolii. Terapia anti-VEGF si-a dovedit eficacitatea in mai multe tipuri de cancer, inclusiv cancerul de col uterin, imbunatatind supravieturiea globala.
Abstract
Cervical intraepithelial neoplasia (CIN) represents a premalignant lesion that can progress to cervical cancer, which is the fourth most common cancer among women. Angiogenesis is a key step in solid tumorigenesis and VEGF plays an important role in this process. VEGF is secreted in large amounts in cervical cancer and its precursors. These peptides stimulate growth and development of endothelial cells, proliferation and differentiation of the new vascular net, helping tumor growth. Several studies have demonstrated that VEGF expression in cervical tissue significantly correlates with CIN severity, cervical cancer stages and prognosis. Genetic polymorphisms can contribute to the susceptibility of individuals for a disease and its severity. Anti-VEGF therapy has proved its usefulness in several types of cancer including cervical location by significantly improved overall survival.
Keywords: neoplazia cervicală intraepitelială, VEGF, angiogeneză
